Assessment on pollution of Ochratoxin A in grain in China and its apoptosis effect on vitro-cultured human tubular kidney cells.
作者： Zengning Li , Xianghong Zhang , Jinfeng Cui , Weijun Kang
DOI: 10.1002/JBT.20420
关键词: Western blot 、 Biology 、 Carcinogen 、 Molecular biology 、 Signal transduction 、 Flow cytometry 、 Kinase 、 Apoptosis 、 Mitogen-activated protein kinase 、 Ochratoxin A
摘要: Ochratoxin A (OTA) is nephrotoxic, immunosuppressive, and teratogenic in many species a possible human carcinogen. In this study, we investigated the OTA pollution situations of grains northern China signaling pathway that mediated OTA-induced apoptosis tubular kidney cells (HKCs). Samples collected from three representative areas were determined by using high-performance liquid chromatography fluorescence method. The effects on cell apoptosis, caspase-3, Bax, Bcl-2 expression, phosphorylation c-Jun NH2 terminal kinase (JNK) detected cultured HKCs via flow cytometry (FCM), Hoechst 33258 staining, Western blot. It showed edible was very common north China. could affect expression increased HKCs. JNK signalling might play an important role during these cellular events. © 2012 Wiley Periodicals, Inc. J Biochem Mol Toxicol 26:139–146, 2012; View article online at wileyonlinelibrary.com. DOI 10.1002/jbt.20420
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