Role of estrogen in the regulation of cholesteryl ester synthesis in macrophages: the interaction between native and modified low density lipoprotein and human monocyte-derived macrophages.
作者： Mariarosaria Napolitano , Annarica Calcabrini , Kathleen M Botham , Elena Bravo
DOI: 10.1016/S0009-9120(02)00404-6
关键词: Endocrinology 、 Internal medicine 、 Cholesterol 、 Signal transduction 、 Macrophage 、 Acetylation 、 Foam cell 、 Cholesteryl ester 、 Estrogen 、 Chemistry 、 Low-density lipoprotein
摘要: Objectives: To study the effects of estrogen on changes in cholesterol esterification induced by native and modified low density lipoprotein (LDL) macrophages. Design methods: Human monocyte-derived macrophages (HMDM) were used, influence presence 17β estradiol short term, during maturation cells, from (nLDL), acetylated (acLDL) oxidized (oxLDL) LDL was determined. Results: In short-term (6 h), (1.5 × 10−6M) did not affect acLDL or oxLDL, but with (nLDL) a 1.5-fold increase observed. contrast, long-term exposure HMDM to 17β-estradiol 10−9M - 1.5 10−5M) decreased oxLDL acLDL, nLDL. Conclusions: These results suggest that both time concentration used its interaction between LDL, thus macrophage foam cell formation.
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