Studies on uracil derivatives and analogs. Syntheses of 5‐(βt‐trimethylsilyl)ethynyluracil and 5‐ethynyluracil
作者： Nitya G. Kundu , Scott A. Schmitz
关键词: Trimethylsilyl 、 Sodium methoxide 、 Ethynyluracil 、 Trimethylsilyl iodide 、 Sodium hydroxide 、 Chemistry 、 Organic chemistry 、 Uracil 、 Methanol 、 Lithium
摘要: 5-(α-Chlorovinyl)-2,4-dichloropyrimidine (I) on treatment with sodium methoxide in methanol was converted to 2,4-dimethoxy-5-ethynylpyrimidine (II) which silylated by t-butyl lithium and chlorotrimethylsilane 2,4-dimethoxy-5-β-trimethylsilyl)ethynylpyrimidine (IV). Compound IV deblocking trimethylsilyl iodide yielded 5-(β-trimethylsilyl)ethynyluracil (V), hydroxide 5-ethynyluracil (VI).
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