Influence of Child and Adult Elevated Blood Pressure on Adult Arterial Stiffness : The Cardiovascular Risk in Young Finns Study

摘要: Elevated blood pressure (BP) in childhood has been associated with increased adult arterial stiffness, the independent predictor of cardiovascular and all-cause mortality. The favorable BP change from to adulthood risk high stiffness not reported. We examined effect child on pulse wave velocity (PWV) assessed among 1540 white adults followed-up for 27 years since baseline (1980, aged 6-18 years). Childhood elevated was defined according tables National High Blood Pressure Education Program. In adulthood, classified as if systolic ≥120 mm Hg, diastolic ≥80 or self-reported use antihypertensive medications. PWV measured 2007 by whole-body impedance cardiography, values at above age-, sex-, heart rate-specific 80th percentile. Individuals persistently individuals normal but had (relative [95% confidence interval], 3.18 [2.22-4.55] 2.64 [1.79-3.88], respectively) comparison (both adult) BP. contrast, did have significantly 1.26[0.80-1.99]). results were consistent when different definitions applied. These findings highlight importance control primary prevention diseases.