Biological evaluation and molecular docking studies of new curcuminoid derivatives: Synthesis and characterization.
作者： Govindharasu Banuppriya , Rajendran Sribalan , Vediappen Padmini , Vellasamy Shanmugaiah
DOI: 10.1016/J.BMCL.2016.02.066
关键词: In vitro 、 Pyrazole 、 Molecular Docking Simulation 、 Curcuminoid 、 Enzyme 、 Curcumin 、 Antioxidant 、 Anti-inflammatory 、 Chemistry 、 Stereochemistry
摘要: In the present study, three series of dimethylamino curcuminoids viz. 4-phenylaminomethyl curcumin (3a-d), arylidene (3e) and pyrazole (3f-i) derivatives have been synthesized studied for their in vitro anti-inflammatory, antioxidant antibacterial activities. Synthesized curcuminoid namely 3d, 3e, 3h 3i shown potent anti-inflammatory properties than parent curcumin. Molecular docking interactions against cyclooxygenase enzymes (COX-1 COX-2) were studied.
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