Non-Alzheimer neurodegenerative pathologies and their combinations are more frequent than commonly believed in the elderly brain: a community-based autopsy series
作者： Herbert Budka , Gabor G. Kovacs , Ivan Milenkovic , Adelheid Wöhrer , Romana Höftberger
DOI: 10.1007/S00401-013-1157-Y
关键词: Pathology 、 Medicine 、 Dementia 、 Tauopathy 、 Alzheimer's disease 、 Alpha-synuclein 、 Hippocampal sclerosis 、 Ageing 、 Cerebral amyloid angiopathy 、 Autopsy
摘要: Neurodegenerative diseases are characterised by neuronal loss and cerebral deposition of proteins with altered physicochemical properties. The major proteins are amyloid-β (Aβ), tau, α-synuclein, and TDP-43. Although neuropathological studies on elderly individuals have emphasised the importance of mixed pathologies, there have been few observations on the full spectrum of proteinopathies in the ageing brain. During a community-based study we performed comprehensive mapping of neurodegeneration-related proteins and vascular …
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