Levels of estrogen receptors alpha and beta in frontal cortex of patients with Alzheimer's disease: relationship to Mini-Mental State Examination scores.
作者： Jeremiah Kelly , Julia Bienias , Avni Shah , Kathleen Meeke , Julie Schneider
DOI: 10.2174/156720508783884611
关键词: Alzheimer's disease 、 Frontal lobe 、 Psychology 、 Internal medicine 、 Alpha (ethology) 、 Estrogen receptor 、 Estrogen receptor alpha 、 Estrogen receptor beta 、 Mini–Mental State Examination 、 Endocrinology 、 Estrogen
摘要: Estrogen exerts beneficial effects on the brain throughout life. Studies demonstrate that estrogen is neuroprotective and reduced activity may influence clinical course of Alzheimer's disease (AD). Changes in levels receptors have been detected postmortem tissue AD patients. Very little known about relationship between stage brain. We hypothesized receptor would be related to severity cognitive impairment assessed proximate death. Western blotting was used quantify ER-alpha ER-beta nuclear, cytosolic, crude membrane fractions superior frontal cortex from 25 Multiple linear regression analyses adjusted for age, sex, education showed a significant Mini-Mental State Examination score (MMSE) wild-type nuclear (â = 5.463, p 0.03), but none MMSE 2.29, 0.36). incidentally observed additional higher lower molecular mass bands study subjects. Additional experiments performed prepared subjects enrolled different confirmed these same are present female males with without AD. Together our data show level AD, also suggest possibility variant isoforms patients
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