Fibroblast growth factor receptors across urothelial carcinoma landscape.
作者： Iris E. Ertl , Shahrokh F. Shariat , Hadi Mostafaei , Dafina Ilijazi , Yohann Loriot
DOI: 10.1097/MOU.0000000000000782
关键词: Fibroblast growth factor 、 Erdafitinib 、 Fibroblast growth factor receptor 、 Clinical trial 、 Carcinogenesis 、 Receptor 、 Carcinoma 、 Biomarker (cell) 、 Cancer research 、 Medicine
摘要: Purpose of review Fibroblast growth factor receptor (FGFR) signalling, especially induced by FGFR3, is a crucial in the pathogenesis urothelial carcinoma and was therefore extensively studied over last decades. In this review, we summarize most relevant findings past two years. Recent studies support concept that FGFR3 mediates pathway carcinogenesis associated with low malignant potential. may represent highly accurate biomarker for diagnosis prediction recurrence, progression or therapy response. The pan FGFR-inhibitor erdafitinib recently approved carcinoma, whereas several other FGFR-targeted drugs are currently undergoing clinical trials. Summary Numerous recent focus on role different subtypes its potential application as noninvasive biomarker, well therapeutic target.
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