Physiologic Mechanisms by Which Local Anesthetics May Cause Injury to Nerve and Spinal Cord

摘要: Objective. Review evidence for possible physiologic mechanisms by which local anesthetics cause nerve injury was reviewed. Methods. Published clinical case reports, and both in vivo vitro experimental studies animals, were Reports with direct bearing on of anesthetic neurotoxicity included. Results. There is basic that can injury. Nerve may result from toxicity to the axon or Schwann cell, be secondary disruption microenvironment. Although each these possibilities supported published experiments, most likely explanation persistent neurologic deficits, such as those believed use anesthetics. Whether indirect, precise mechanism it occurs, has received only limited study. Conclusions. In rare instances, associated morbidity. The there best are inhibition fast axonal transport, cytoskeleton, degeneration, ischemic effects blood flow related endothelium-dependent vasodilation interruption synthesis vasodilating prostaglandins. Both prevention treatment caused requires information not yet available about molecular neural