OLMα2 Cells Bidirectionally Modulate Learning.
作者： Samer Siwani , Arthur S.C. França , Sanja Mikulovic , Amilcar Reis , Markus M. Hilscher
DOI: 10.1016/J.NEURON.2018.06.022
关键词: Cell activation 、 Neuroscience 、 Inhibitory postsynaptic potential 、 Selective modulation 、 Nicotine 、 Receptor 、 Nicotinic agonist 、 Interneuron 、 Biology 、 α2 subunit
摘要: Summary Inhibitory interneurons participate in mnemonic processes. However, defined roles for identified interneuron populations are scarce. A subpopulation of oriens lacunosum-moleculare (OLM) genetically by the expression nicotinic receptor α2 subunit has been shown to gate information carried either temporoammonic pathway or Schaffer collaterals in vitro. Here we set out determine whether selective modulation OLMα2 cells intermediate CA1 affects learning and memory in vivo. Our data show that can enhance (upon their inhibition) impair activation) object encoding freely moving mice, thus exerting bidirectional control. Moreover, find cell activation inhibits fear-related memories respond differently nicotine dorsoventral axis. These results suggest an important component microcircuit regulating Video Abstract Download : video (54MB)
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