Production of plasmid-encoding NDM-1 in clinical Raoultella ornithinolytica and Leclercia adecarboxylata from China.
作者： Fengjun Sun , Zhe Yin , Jiao Feng , Yefeng Qiu , Defu Zhang
关键词: Carbapenem resistance 、 Bioinformatics 、 Transposition (music) 、 Leclercia adecarboxylata 、 Gene 、 Inverted repeat 、 Genetics 、 Plasmid 、 Biology 、 Raoultella ornithinolytica
摘要: Raoultella ornithinolytica YNKP001 and Leclercia adecarboxylata P10164, harboring conjugative plasmids pYNKP001-NDM pP10164-NDM with determination of complete nucleotide sequences, respectively, were isolated from two different Chinese patients. Production NDM-1 enzyme by these accounts for carbapenem resistance strains. This is the first report blaNDM in L. third this gene R. ornithinolytica. very similar to IncN2 NDM-1-encoding pTR3, pNDM-ECS01 p271A, while IncFIIY blaNDM-1-carrying plasmid pKOX_NDM1. The blaNDM-1 genes are embedded Tn125-like elements, which represent distinct truncated versions prototype Tn125 as observed pNDM-BJ01. Flanking elements miniature inverted repeat element (MITE) or its remnant denotes MITE felicitates transposition mobilization contexts.
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