Circulating miR-127-3p as a Potential Biomarker for Differential Diagnosis in Frontotemporal Dementia.

摘要: Given the heterogeneous nature of frontotemporal dementia (FTD), sensitive biomarkers are greatly needed for accurate diagnosis this neurodegenerative disorder. Circulating miRNAs have been reported as promising disorders and processes affecting central nervous system, especially in aging. The objective study was to evaluate if some circulating linked with apoptosis (miR-29b-3p, miR-34a-5p, miR-16-5p, miR-17-5p, miR-107, miR-19b-3p, let-7b-5p, miR-26b-5p, 127-3p) were able distinguish between FTD patients healthy controls. For study, we enrolled 127 subjects, including 54 FTD, 20 Alzheimer's disease (AD), 53 qRT-PCR analysis showed a downregulation miR-127-3p compared controls, while levels other remained unchanged. Then, expression also analyzed AD patients, finding different two patient groups. A receiver operating characteristic curve then created discriminate versus (AUC: 0.8986), controls 0.8057). In conclusion, could help diagnose it from AD.