FXR-deficiency confers increased susceptibility to torpor
作者： Bertrand Cariou , Emmanuel Bouchaert , Mouaadh Abdelkarim , Julie Dumont , Sandrine Caron
DOI: 10.1016/J.FEBSLET.2007.09.064
关键词: Nuclear receptor 、 Biology 、 Thermogenesis 、 Energy homeostasis 、 Adipose tissue 、 Endocrinology 、 Internal medicine 、 Brown adipose tissue 、 Torpor 、 Farnesoid X receptor 、 Uncoupling protein
摘要: The role of the nuclear receptor FXR in adaptive thermogenesis was investigated using FXR-deficient mice. Despite elevated serum bile acid concentrations and increased mRNA expression profiles thermogenic genes brown adipose tissue, FXR-deficiency did not alter energy expenditure under basal conditions. However, accelerated fasting-induced entry into torpor a leptin-dependent manner. mice were also extremely cold-intolerant. These altered responses may be linked to more rapid decrease plasma metabolic fuels (glucose, triglycerides) thus impairing uncoupling protein 1-driven thermogenesis. results identify as modulator homeostasis.
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