Contribution and interaction of kinin receptors and dynorphin A in a model of trigeminal neuropathic pain in mice.
作者： A.P. Luiz , S.D. Schroeder , G.A. Rae , J.B. Calixto , J.G. Chichorro
DOI: 10.1016/J.NEUROSCIENCE.2015.05.015
关键词: Anesthesia 、 Nociception 、 Kinin 、 Receptor antagonist 、 Neuropathic pain 、 Antagonist 、 Infraorbital nerve 、 Medicine 、 Endocrinology 、 Dynorphin A 、 Receptor 、 Internal medicine
摘要: Infraorbital nerve constriction (CION) causes hypersensitivity to facial mechanical, heat and cold stimulation in rats mice is a reliable model study trigeminal neuropathic pain. In this there evidence that mechanisms operated by kinin B1 B2 receptors contribute hyperalgesia both mice. Herein we further explored issue assessed the role of mechanical after CION. Swiss C57Bl/6 underwent CION or sham surgery dynorphin A (1-17) administration were repeatedly submitted application either stimuli snout forehead. Treatment animals on fifth day with DALBK (B1 receptor antagonist) HOE-140 (B2 antagonist), at 0.01-1μmol/kg (i.p.), effectively reduced CION-induced hyperalgesia. Knockout for B1, B1/B2 did not develop response Subarachnoid delivery (15nmol/5μL) also resulted orofacial hyperalgesia, which was attenuated post-treatment (1 3μmol/kg, i.p.), but affected HOE-140. Additionally, treatment an anti-dynorphin antiserum (200μg/5μL, s.a.) up 2h. These results suggest are relevant sensory nociceptive changes induced Furthermore, they indicate could stimulate effect seems maintenance
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