Genetic polymorphisms of the adenosine triphosphate-binding cassette transporters (ABCG2, ABCB1) and gefitinib toxicity

摘要: The purpose of this study is to investigate associations between allelic variations ABCG2 and ABCB1 with skin toxicity, diarrhea, liver injury interstitial lung disease (ILD) in gefitinib-treated patients. A prospective clinical 83 Japanese patients non-small-cell cancer was performed. Polymorphic loci were genotyped, their effects on gefitinib toxicities evaluated. 34G>A statistically associated occurrence rash; 13 (42%) the 32 at least one variant allele (G/A A/A) developed grade 2 or worse rash, whereas only 10 (19%) 51 homozygous for reference (G/G) wild-type sequence both alleles did so (P=0.046). There no significant association severe polymorphisms 421C>A nor 3435C>T. results suggested that would be useful predicting rash.