Pro-nociceptive and anti-nociceptive effects of a conditioned pain modulation protocol in participants with chronic low back pain and healthy control subjects.
作者： Martin Rabey , Cheryl Poon , Jonathan Wray , Chutiporn Thamajaree , Ryan East
DOI: 10.1016/J.MATH.2015.02.011
关键词: Stimulus (physiology) 、 Nociception 、 Cohort 、 Anesthesia 、 Medicine 、 Conditioned pain modulation 、 Physical medicine and rehabilitation 、 Lumbar 、 Healthy control 、 Chronic pain 、 Chronic low back pain
摘要: Abstract Background People with chronic pain may exhibit pro-nociceptive phenotypes characterised partly by reduced conditioned modulation (CPM). Characterising variability in CPM people low back (CLBP) inform management. Objectives To investigate pro/anti-nociceptive effects of a protocol age/sex-matched healthy controls (HCs) and CLBP. Design Case-controlled trial (64 participants/group). Method The involved: test stimulus (TS) (noxious pressure applied algometer to lumbar region); conditioning (CS) heat thermode dorsal hand). recruitment was measured the change intensity (rated on numeric rating scale (NRS)) TS presence absence CS. Results Responses this were variable for both groups measures consistent either inhibitory or facilitatory effects. A significantly greater proportion responses seen CLBP cohort compared HCs (73% versus 31%). In response CS, participants demonstrated mean increase NRS scores (mean 1.3 points; p = 0.35) between-group difference significant 1.4 Conclusion elicited varying higher demonstrating suggests phenotype characterise cohort.
curtin.edu.au参考文章(52)
Monika I. Hasenbring, Adina C. Rusu, Dennis C Turk, From Acute to Chronic Back Pain: Risk Factors, Mechanisms, and Clinical Implications ,(2012)
Stéphanie Cormier, Mathieu Piché, Pierre Rainville, Expectations modulate heterotopic noxious counter-stimulation analgesia. The Journal of Pain. ,vol. 14, pp. 114- 125 ,(2013) , 10.1016/J.JPAIN.2012.10.006
A D. Skyba, R Radhakrishnan, J J. Rohlwing, A Wright, A K. Sluka, Joint manipulation reduces hyperalgesia by activation of monoamine receptors but not opioid or GABA receptors in the spinal cord Pain. ,vol. 106, pp. 159- 168 ,(2003) , 10.1016/S0304-3959(03)00320-8
Ronald Dubner, Ke Ren, ENDOGENOUS MECHANISMS OF SENSORY MODULATION Pain. ,vol. 82, ,(1999) , 10.1016/S0304-3959(99)00137-2
Daniel Le Bars, The whole body receptive field of dorsal horn multireceptive neurones Brain Research Reviews. ,vol. 40, pp. 29- 44 ,(2002) , 10.1016/S0165-0173(02)00186-8
Lone Knudsen, Gitte Laue Petersen, Kathrine Næsted Nørskov, Lene Vase, Nanna Finnerup, Troels Staehelin Jensen, Peter Svensson, Review of neuroimaging studies related to pain modulation Scandinavian Journal of Pain. ,vol. 2, pp. 108- 120 ,(2011) , 10.1016/J.SJPAIN.2011.05.005
Dorit Pud, Elliot Sprecher, David Yarnitsky, Homotopic and heterotopic effects of endogenous analgesia in healthy volunteers Neuroscience Letters. ,vol. 380, pp. 209- 213 ,(2005) , 10.1016/J.NEULET.2005.01.037
David Yarnitsky, Michal Granot, Yelena Granovsky, Pain modulation profile and pain therapy: Between pro- and antinociception Pain. ,vol. 155, pp. 663- 665 ,(2014) , 10.1016/J.PAIN.2013.11.005
Ruth Moont, Dorit Pud, Elliot Sprecher, Gil Sharvit, David Yarnitsky, ‘Pain inhibits pain’ mechanisms: Is pain modulation simply due to distraction? Pain. ,vol. 150, pp. 113- 120 ,(2010) , 10.1016/J.PAIN.2010.04.009
Alban Y. Neziri, Michele Curatolo, Andreas Limacher, Eveline Nüesch, Bogdan Radanov, Ole K. Andersen, Lars Arendt-Nielsen, Peter Jüni, Ranking of parameters of pain hypersensitivity according to their discriminative ability in chronic low back pain Pain. ,vol. 153, pp. 2083- 2091 ,(2012) , 10.1016/J.PAIN.2012.06.025