NITRITE AND THIOSULFATE THERAPY IN CYANIDE POISONING

摘要: In 1932 Geiger 1 began to use methylene blue in treatment of cyanide poisoning. The antidotal action the dye was shown by Wendel 2 and Hug 3 be due formation methemoglobin, which successfully competes with respiratory enzyme, ferricytochrome oxidase, for ions. Subsequent reports 4 indicate that is not an efficient antidote because it a poor methemoglobin former at same time reverses reaction presence co-enzyme. 5 fact, greater value methemoglobinemia 6 than Nevertheless, trial stimulated renewed search antidotes, led discovery more effective therapy. Independent investigations Argentina 7 United States 4a gave rise clear-cut conclusion combination sodium nitrite thiosulfate, consecutively injected vein,