Molecular geometry and mechanisms of action of chemical carcinogens.

摘要: Since the discovery, between 1930 and 1940, of carcinogenic activity certain polycyclic aromatic hydrocarbons azo dyes, innumerable chemical agents have been tested. It is probably not exaggerated to say that at pre-sent time number known ways tumor induction approaches a thousand includes such heterogenous etiologic factors as structurally defined carcinogens, unknown composition, viruses, physical agents, various types experimentally produced systemic hor-monal imbalances. Until about 1950, however, classification carcinogens was relatively simple since great majority compounds could be grouped either condensed or amines, this last group including benzacridines amino dyes. Various theories were proposed account for producing ability chemicals falling into these two categories. A limited correlation established reactivity in terms π-electron distribution molecular regions angular benzacridines. Attempts subsequently made include dyes other amines theories.