A magnetic vehicle realized tumor cell-targeted radiotherapy using low-dose radiation.

摘要: Radiotherapy, a common cancer treatment, often adversely affects the surrounding healthy tissue and/or cells. Some tumor tissue-focused radiation therapies have been developed to lower radiation-induced lesion formation; however, achieving cell-targeted radiotherapy (i.e., precisely focusing efficacy cells) remains challenge. In present study, we novel radiotherapy, named targeted sensitization-enhanced (TSER), that exploits tumor-specific folic acid-conjugated carboxymethyl lauryl chitosan/superparamagnetic iron oxide (FA-CLC/SPIO) micelles effectively deliver chlorin e6 (Ce6, sonosensitizer) mitochondria of HeLa cells under magnetic guidance. For in vitro tests, sensitization Ce6 induced by ultrasound, could weaken resistant ability cells, occurred only Ce6-internalizing Therefore, low-dose X-ray irradiation, was not harmful normal exert high cell-specific killing ability. The ratio viable increased considerably, from 7.8 (at 24h) 97.1 72h), after they had received TSER treatment. Our data suggest treatment significantly weakens resulting decreased viability as well vivo subcutaneous growth nude mice, while adverse effects were minimal. Taken together, appears be an effective, clinically feasible can solve problems traditional and photodynamic therapy.