Biomarkers for pin1-associated disorders

摘要: Biomarkers and driver mutations for diagnosis prognosis of Pin 1 -associated diseases are disclosed. In one embodiment, the methods may include detecting level Pin1 to stage abnormal cell growth, such as breast or prostate cancer. another evaluating efficacy a treatment cancer, by monitoring levels Pin1. using determine pharmacogenetics present disclosure, elevated active monomeric be detected biomarkers, which Q33K E100D mutations, protein transcript overexpression, dephosphorylation on Ser71, S16, phosphorylation S65, S138, deacetylation K13 K46, and/or desumoylation K6 desumolation K63, among others.