Molecular genetic contributions to self-rated health

摘要: Background Poorer self-rated health (SRH) predicts worse outcomes, even when adjusted for objective measures of disease at time rating. Twin studies indicate SRH has a heritability 18-60% and that its genetic architecture may overlap personality cognition. Methods We carried out genome-wide association study (GWAS) on 111 749 members the UK Biobank sample. Univariate GCTA-GREML analyses were used to estimate proportion variance explained by all common autosomal SNPs SRH. LD score regression polygenic risk scoring investigate pleiotropy between in up 21 health-related cognitive traits from published GWAS consortia. Results The identified 13 independent signals associated with SRH, including several regions previously diseases or disease-related traits. strongest signal was chromosome 2 (rs2360675, p = 1.77x10-10) close KLF7, which been obesity type diabetes. A second strong peak 6 major histocompatibility region (rs76380179, 6.15x10-10). variants 13%. Polygenic scores following disorders SRH: ability, education, neuroticism, BMI, longevity, ADHD, depressive disorder, schizophrenia, lung function, blood pressure, coronary artery disease, large vessel stroke, Conclusions Individual differences how people respond single item are partly their propensity many psychiatric physical psychological