Use of cobratoxin as an analgesic
作者： Paul F. Reid , Zheng Hong Qin
DOI:
关键词: Acetylcholine 、 Cobratoxin 、 Acetylcholine receptor 、 Chronic pain 、 Intractable pain 、 Rheumatoid arthritis 、 Nicotinic agonist 、 Analgesic 、 Pharmacology 、 Medicine
摘要: A composition of matter for an analgesia and its method use is disclosed. The the treatment chronic pain, especially to heretofore intractable pain as associated with advanced cancer. neurological conditions, rheumatoid arthritis, viral infections lesions also contemplated. includes administering a host alpha-neurotoxin that characterized by ability blocking action acetylcholine at nicotinic receptors.
lens.org参考文章(9)
Paul Reid, Laurence Raymond, Modified neurotoxins as therapeutic agents for the treatment of diseases and methods of making ,(2003)
Zheng-Hong Qin, Zhen-Lun Gu, Rong Han, Paul F Reid, Laurence N Raymond, Hui-Ling Zhang, Zhi-Xing Chen, Analgesic effects of receptin, a chemically modified cobratoxin from Thailand cobra venom. Neuroscience Bulletin. ,vol. 22, pp. 267- 273 ,(2006)
Paul Reid, Laurence Raymond, Modified alpha-neurotoxins as painkillers ,(2003)
William E. Haast, Use of snake venoms for treatment of neurological and related disorders ,(1981)
W. Glassco, M. Dukat, B. R. Martin, R. A. Glennon, M. Fei-Yin, M. I. Damaj, Antinociceptive Responses to Nicotinic Acetylcholine Receptor Ligands after Systemic and Intrathecal Administration in Mice Journal of Pharmacology and Experimental Therapeutics. ,vol. 284, pp. 1058- 1065 ,(1998)
Stéphanie Antil-Delbeke, Carole Gaillard, Toru Tamiya, Pierre-Jean Corringer, Jean-Pierre Changeux, Denis Servent, André Ménez, Molecular Determinants by Which a Long Chain Toxin from Snake Venom Interacts with the Neuronal α7-Nicotinic Acetylcholine Receptor * Journal of Biological Chemistry. ,vol. 275, pp. 29594- 29601 ,(2000) , 10.1074/JBC.M909746199
D. I. Macht, Experimental and Clinical Study of Cobra Venom as an Analgesic. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 22, pp. 61- 71 ,(1936) , 10.1073/PNAS.22.1.61
X.C. Pu, P.T.H. Wong, P. Gopalakrishnakone, A novel analgesic toxin (hannalgesin) from the venom of king cobra (Ophiophagus hannah) Toxicon. ,vol. 33, pp. 1425- 1431 ,(1995) , 10.1016/0041-0101(95)00096-5
Zheng-Hong Qin, Zhen-Lun Gu, Rong Han, Paul F Reid, Laurence N Raymond, Bo-Wen Chen, Hui-Ling Zhang, Zhi-Xing Chen, A short-chain alpha-neurotoxin from Naja naja atra produces potent cholinergic-dependent analgesia. Neuroscience Bulletin. ,vol. 22, pp. 103- 109 ,(2006)