Stereocontrol in a combined allylic azide rearrangement and intramolecular Schmidt reaction.
作者： Ruzhang Liu , Osvaldo Gutierrez , Dean J. Tantillo , Jeffrey Aubé
DOI: 10.1021/JA300369C
关键词: Enantioselective synthesis 、 Allylic rearrangement 、 Stereoisomerism 、 Intramolecular force 、 Schmidt reaction 、 Context (language use) 、 Chemistry 、 Pinnaic acid 、 Stereochemistry 、 Azide
摘要: Pre-equilibration of an interconverting set isomeric allylic azides is coupled with intramolecular Schmidt reaction to afford substituted lactams stereoselectively. The effect substitution and a preliminary mechanistic study are reported. synthetic potential this method demonstrated in the context enantioselective synthesis advanced intermediate leading toward pinnaic acid.
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