Neutrophils: fast and furious-the nucleotide pathway.

摘要: Nucleotide signaling is a key element of the neutrophil activation pathway. Neutrophil recruitment and migration to injured tissues guided by purinergic receptor sensitization, mostly induced extracellular adenosine triphosphate (ATP) its hydrolysis product, (ADO), which primarily produced CD39-CD73 axis located at cell surface. In inflammation unrelated cancer, via aims eliminate antigens promote an immune response with minimal damage healthy tissues; however, antagonistic may be expected in tumors. Indeed, alterations favor accumulation ATP ADO microenvironment solid tumors, tumor progression inducing proliferation, angiogenesis, escape from surveillance. Since neutrophils their N1/N2 polarization spectrum are being considered new components cancer-related inflammation, participation pro-tumor activities should also considered. However, there lack studies investigating human tumor-associated neutrophils. this review, we discussed elicited nucleotides extrapolated behavior context cancer. Understanding these mechanisms cancerous conditions help identify biological targets therapeutic strategies, particularly regarding tumors that refractory traditional chemo- immunotherapy.