Conditionally Pathogenic Gut Microbes Promote Larval Growth by Increasing Redox-Dependent Fat Storage in High-Sugar Diet-Fed Drosophila.
作者： Tae Woong Whon , Na-Ri Shin , Mi-Ja Jung , Dong-Wook Hyun , Hyun Sik Kim
关键词: Protein kinase A 、 Biology 、 Gut flora 、 Symbiosis 、 Lipid metabolism 、 Drosophila melanogaster 、 Microbiology 、 Bacteria 、 Drosophila 、 Axenic 、 Biochemistry
摘要: Abstract Aims: Changes in the composition of gut microbiota contribute to development obesity and subsequent complications that are associated with metabolic syndrome. However, role increased numbers certain bacterial species during progress factor(s) controlling community structure remain unclear. Here, we demonstrate inter-relationship between Drosophila melanogaster their resident under chronic high-sugar diet (HSD) conditions. Results: Chronic feeding an HSD resulted a predominance uracil-secreting bacteria gut. Axenic insects mono-associated or supplemented uracil conditions promoted larval development. Redox signaling induced by growth regulating sugar lipid metabolism via activation p38a mitogen-activated protein kinase. Innovation: The present study identified new redox-dependent mechan...
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