Translational neuroimaging: positron emission tomography studies of monoamine oxidase.
作者： Joanna S. Fowler , Jean Logan , Nora D. Volkow , Gene-Jack Wang
DOI: 10.1007/S11307-005-0016-1
关键词: Monoamine oxidase A 、 Biochemistry 、 Pharmacology 、 Dopamine 、 Monoamine oxidase B 、 Monoamine oxidase 、 Clorgyline 、 Chemistry 、 Serotonin 、 Norepinephrine 、 Tyramine
摘要: Positron emission tomography (PET) using radiotracers with high molecular specificity is an important scientific tool in studies of monoamine oxidase (MAO), enzyme the regulation neurotransmitters dopamine, norepinephrine, and serotonin as well dietary amine, tyramine. MAO occurs two different subtypes, A B, which have substrate inhibitor are gene products. The highly variable subtype distribution species makes human special value. B can be imaged brain certain peripheral organs PET carbon-11 (half-life 20.4 minutes) labeled mechanism-based irreversible inhibitors, clorgyline l-deprenyl, respectively. In this article we introduce describe development these their translation from preclinical to investigation variables affecting organs.
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sci-hub.se 参考文章(88)
Mary Lilias Christian Hare, Tyramine oxidase: A new enzyme system in liver. Biochemical Journal. ,vol. 22, pp. 968- 979 ,(1928) , 10.1042/BJ0220968
E. Albert Zeller, James Barsky, Elaine R. Berman, Amine oxidases. XI. Inhibition of monoamine oxidase by 1-isonicotinyl-2-isopropylhydrazine. Journal of Biological Chemistry. ,vol. 214, pp. 267- 274 ,(1955) , 10.1016/S0021-9258(18)70965-4
Prevalence of smoking among psychiatric outpatients. American Journal of Psychiatry. ,vol. 143, pp. 993- 997 ,(1986) , 10.1176/AJP.143.8.993
J. S. Fowler, J. Logan, Y.-S. Ding, D. Franceschi, G.-J. Wang, N. D. Volkow, N. Pappas, D. Schlyer, S. J. Gatley, D. Alexoff, C. Felder, A. Biegon, W. Zhu, Non-MAO A binding of clorgyline in white matter in human brain. Journal of Neurochemistry. ,vol. 79, pp. 1039- 1046 ,(2008) , 10.1046/J.1471-4159.2001.00649.X
Dean Hamer, Rethinking Behavior Genetics Science. ,vol. 298, pp. 71- 72 ,(2002) , 10.1126/SCIENCE.1077582
Joanna S Fowler, Gene-Jack Wang, Jean Logan, Shan Xie, Nora D Volkow, Robert R MacGregor, David J Schlyer, Naomi Pappas, David L Alexoff, Clifford Patlak, Alfred P Wolf, Selective reduction of radiotracer trapping by deuterium substitution : comparison of carbon-11-L-deprenyl and carbon-11-deprenyl-D2 for MAO B mapping The Journal of Nuclear Medicine. ,vol. 36, pp. 1255- 1262 ,(1995)
Markus Haass, Wolfgang K�bler, Nicotine and sympathetic neurotransmission Cardiovascular Drugs and Therapy. ,vol. 10, pp. 657- 665 ,(1997) , 10.1007/BF00053022
Joanna S Fowler, Jean Logan, Gene-Jack Wang, Nora D Volkow, Frank Telang, Yu-Shin Ding, Colleen Shea, Victor Garza, Youwen Xu, Zizhong Li, David Alexoff, Paul Vaska, Richard Ferrieri, David Schlyer, Wei Zhu, S John Gatley, None, Comparison of the binding of the irreversible monoamine oxidase tracers, [11C]clorgyline and [11C]l-deprenyl in brain and peripheral organs in humans Nuclear Medicine and Biology. ,vol. 31, pp. 313- 319 ,(2004) , 10.1016/J.NUCMEDBIO.2003.10.003
K Chen, Organization of MAO A and MAO B promoters and regulation of gene expression Neurotoxicology. ,vol. 25, pp. 31- 36 ,(2004) , 10.1016/S0161-813X(03)00113-X
J.P. Johnston, Some observations upon a new inhibitor of monoamine oxidase in brain tissue. Biochemical Pharmacology. ,vol. 17, pp. 1285- 1297 ,(1968) , 10.1016/0006-2952(68)90066-X