Frustrative nonreward: Chemogenetic inactivation of the central amygdala abolishes the effect of reward downshift without affecting alcohol intake.
作者： Sara Guarino , Shannon E. Conrad , Mauricio R. Papini
DOI: 10.1016/J.NLM.2020.107173
关键词: Clozapine 、 Internal medicine 、 Alcohol consumption 、 Alcohol 、 Endocrinology 、 Sucrose 、 In vehicle 、 Neuroscience 、 Amygdala 、 Alcohol intake 、 Negative contrast 、 Chemistry
摘要: Abstract The role of the central amygdala (CeA) in adjustment to a 32-to-2% sucrose downshift consummatory successive negative contrast (cSNC) task and free-choice 10% alcohol-water preference (PT) was studied using chemogenetic inactivation. cSNC is model frustrative nonreward that enhances alcohol consumption. In Experiment 1, sessions 1–10 involved 5-min access 32% 11–12 2% sucrose. Vehicle or clozapine N-oxide (CNO; 1 3 mg/kg, ip), used later activate inhibitory designer receptor, administered 30 min before 11–12. There no evidence CNO affected behavior after downshift. 2, all animals received an infusion receptor hM4D(Gi) into CeA. After recovery, either on 1–10, followed by Immediately each session, 2-bottle, 1-h PT with water. (3 mg/kg, ip) vehicle CeA inactivation prior eliminated effect, which observed controls. However, there for over These results support hypothesis activity critical outcome consistent view plays nonreward.
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