African Burkitt's lymphoma. History, biology, clinical features, and treatment.

摘要: Dennis Burkitt's first description of the African tumor that is now known by his name appeared in 1958. In brief intervening span 32 years, this lymphoma has provided an extraordinarily valuable paradigm afforded insights into topics encompass entire discipline oncology. These include origins lymphoid neoplasms at epidemiological, cellular, and molecular levels, efficacy chemotherapy rapidly progressive, widely disseminated lymphomas. addition, epidemiological considerations led to discovery a new virus, Epstein-Barr which proved be important human pathogen. This virus probably plays pathogenetic role several neoplastic diseases, including lymphoproliferative syndromes associated with inherited acquired immunodeficiency. Small, noncleaved cell latest histological designation category lymphomas includes lymphoma. tumor, biologically heterogeneous, become notorious because its high incidence individuals infected immunodeficiency providing second, potentially fertile model for exploration pathogenesis neoplasms. Already, enough permit tentative steps toward development novel therapeutic approaches directed genetic abnormalities neoplasm. article, history, biology, clinical features, treatment are reviewed.