First pass biotransformation of ethinylestradiol in rat small intestine in situ
作者： Michael Schwenk , Carmen Schiemenz , Victor Lopez del Pino , Herbert Remmer
DOI: 10.1007/BF00505490
关键词: Endocrinology 、 Absorption (skin) 、 Biotransformation 、 Chemistry 、 Glucuronidation 、 Intestinal absorption 、 Ethinylestradiol 、 Glucuronide 、 Internal medicine 、 Bioavailability 、 Metabolism 、 Pharmacology 、 General Medicine
摘要: The intestinal absorption and biotransformation of ethinylestradiol glucuronide in rats were studied using a jejunal loop preparation situ. Radioactivity associated with amost completely appeared the venous outflow within 80 min. Forty two percent was present as unchanged compond, 56% fraction 2% sulfate ester. Absorption about 20 times slower than nonconjugated molecule. data indicate, that involves several superimposed kinetics glucuronidation gut may result decreased bioavailability compound.
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