Interactions Between Sendai Virus and Human Erythrocytes

摘要: Abstract Concentrated Sendai virus, when adsorbed to erythrocytes at 4 C, caused invaginations in the plasma membrane. Following elevation of temperature 37 membrane became fused with viral envelope before dissolution virions and rupture cells. Cell lysis was accompanied by rapid total loss hemoglobin extracellular space. aqueous pyridine extraction, hemoglobin-free ghosts remaining were found be devoid N-acetylneuraminic acid have solubility properties different from those normal erythrocyte ghosts. By action neuraminidase, bound also liberated purified virus receptor substance whose electrophoretic mobility thereby substantially reduced. Cu++ selectively inhibited hemolysis neuraminidase without interfering hemagglutination attachment. Neuraminidase appeared essential for hemolysis; particle size may a critical factor this process.