Heart failure with preserved ejection fraction in the elderly: scope of the problem.

摘要: Heart failure with preserved ejection fraction (HFpEF) is the most common form of heart (HF) in older adults, particularly women, and increasing prevalence as population ages. With morbidity mortality on par HF reduced fraction, it remains a challenging clinical syndrome for practicing clinician basic research scientist. Originally considered to be predominantly caused by diastolic dysfunction, more recent insights indicate that HFpEF persons typified broad range cardiac non-cardiac abnormalities reserve capacity multiple organ systems. The globally driven by: 1) inherent age-related changes; 2) multiple, concomitant co-morbidities; 3) itself, which likely systemic disorder. These help explain why: co-morbidities are among strongest predictors outcomes; approximately 50% events patients non-cardiovascular; drug trials have been negative their primary outcomes. Embracing true geriatric syndrome, complex, multi-factorial pathophysiology heterogeneity could provide new mechanistic opportunities progress management. This article part Special Issue entitled CV Aging.