Dietary mercury exposure in a population with a wide range of fish consumption--self-capture of fish and regional differences are important determinants of mercury in blood.

摘要: Abstract Human, low level, chronic exposure to mercury (Hg) from fish is of concern because potential neurodevelopmental and cardiovascular toxicity. The purpose the study was 1) measure total (THg) in blood estimate dietary a population group with wide range seafood consumption, 2) assess intake concentration relation tolerable values, 3) characterise sources, 4) investigate relationship between THg (BTHg), including factors that can explain variance BTHg concentrations. participants (n = 184) filled an extensive food frequency questionnaire which combined database on concentrations Norwegian food, donated urine. Median consumption 65 g/day (range 4 341 g/day). calculated mean 0.35 (median 0.30) μg/kg body weight/week. Seafood contributed average 95% exposure. JECFA Provisional Tolerable Weekly Intake (PTWI) 1.6 μg MeHg/kg bw/week not exceeded by any participants. ranged 0.6 30 μg/L, 5.3 4.0 μg/L). There strong (r = 0.58 95%CI: 0.48, 0.67) estimated (r = 0.46 0.35, 0.57). Fish sex, catching > 50% their themselves, living coastal municipalities were significant linear regression models lnBTHg. Including urinary Hg model increased explained 54% 65%. In toxicokinetic model, appeared moderately underestimate measured among highest BTHg. Only two had slightly above value equivalent PTWI, but none them women fertile age.