chronic heart failure (MERIT-HF) Analysis of the experience in metoprolol CR/XL randomized intervention trial in Dose of metoprolol CR/XL and clinical outcomes in patients with heart failure:

Magnar Ervik, Kerstin Kylberg-Hanssen, Lars Johansson, Determination of metoprolol in plasma and urine using high-resolution gas chromatography and electron-capture detection Journal of Chromatography B: Biomedical Sciences and Applications. ,vol. 381, pp. 168- 174 ,(1986) , 10.1016/S0378-4347(00)83577-X

Michael R. Bristow, Robert Ginsburg, Wayne Minobe, Roger S. Cubicciotti, W. Scott Sageman, Keith Lurie, Margaret E. Billingham, Donald C. Harrison, Edward B. Stinson, Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts New England Journal of Medicine. ,vol. 307, pp. 205- 211 ,(1982) , 10.1056/NEJM198207223070401

E M Gilbert, C C Eiswirth, P C Mealey, P Larrabee, C M Herrick, M R Bristow, Beta-adrenergic supersensitivity of the transplanted human heart is presynaptic in origin. Circulation. ,vol. 79, pp. 344- 349 ,(1989) , 10.1161/01.CIR.79.2.344

J. Wikstrand, MERIT-HF--description of the trial Basic Research in Cardiology. ,vol. 95, ,(2000) , 10.1007/S003950070016

F Waagstein, K Caidahl, I Wallentin, C H Bergh, A Hjalmarson, Long-term beta-blockade in dilated cardiomyopathy. Effects of short- and long-term metoprolol treatment followed by withdrawal and readministration of metoprolol. Circulation. ,vol. 80, pp. 551- 563 ,(1989) , 10.1161/01.CIR.80.3.551

Michael R Bristow, Edward M Gilbert, William T Abraham, Kirkwood F Adams, Michael B Fowler, Ray E Hershberger, Spencer H Kubo, Kenneth A Narahara, Henry Ingersoll, Steven Krueger, Sarah Young, Neil Shusterman, None, Carvedilol Produces Dose-Related Improvements in Left Ventricular Function and Survival in Subjects With Chronic Heart Failure Circulation. ,vol. 94, pp. 2807- 2816 ,(1996) , 10.1161/01.CIR.94.11.2807

Stephen S. Gottlieb, Michael L. Fisher, John Kjekshus, Prakash Deedwania, Lars Gullestad, Jiri Vitovec, John Wikstrand, Tolerability of β-Blocker Initiation and Titration in the Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure (MERIT-HF) Circulation. ,vol. 105, pp. 1182- 1188 ,(2002) , 10.1161/HC1002.105180

Åke Hjalmarson, Sidney Goldstein, Björn Fagerberg, Hans Wedel, Finn Waagstein, John Kjekshus, John Wikstrand, Dia El Allaf, Jirí Vítovec, Jan Aldershvile, Matti Halinen, Rainer Dietz, Karl-Ludwig Neuhaus, András Jánosi, Gudmundur Thorgeirsson, Peter HJM Dunselman, Lars Gullestad, Jerzy Kuch, Johan Herlitz, Peter Rickenbacher, Stephen Ball, Stephen Gottlieb, Prakash Deedwania, MERIT-HF Study Group, MERIT-HF Study Group, Effects of Controlled-Release Metoprolol on Total Mortality, Hospitalizations, and Well-being in Patients with Heart Failure: The Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure (MERIT-HF) Survey of Anesthesiology. ,vol. 44, pp. 343- 344 ,(2000) , 10.1097/00132586-200012000-00023

Milton Packer, Michael B. Fowler, Ellen B. Roecker, Andrew J.S. Coats, Hugo A. Katus, Henry Krum, Paul Mohacsi, Jean L. Rouleau, Michal Tendera, Christoph Staiger, Terry L. Holcslaw, Ildiko Amann-Zalan, David L. DeMets, Effect of Carvedilol on the Morbidity of Patients With Severe Chronic Heart Failure Results of the Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) Study Circulation. ,vol. 106, pp. 2194- 2199 ,(2002) , 10.1161/01.CIR.0000035653.72855.BF

The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial The Lancet. ,vol. 353, pp. 9- 13 ,(1999) , 10.1016/S0140-6736(98)11181-9