Acylation of Bowman-Birk soybean proteinase inhibitor by unsaturated fatty acid derivatives.
作者： E. V. Malykh , O. P. Tiourina , N. I. Larionova
关键词: Yield (chemistry) 、 Proteinase inhibitor 、 Organic chemistry 、 Thermostability 、 Chemistry 、 Bowman birk 、 Molecule 、 Stereochemistry 、 Unsaturated fatty acid 、 Bioorganic chemistry 、 Acylation
摘要: A procedure was developed for acylation of Bowman–Birk soybean proteinase inhibitor (BBI) by N-hydroxysuc-cinimide esters oleic, linoleic, and α-linolenic acids in a dimethyl sulfoxide–dioxane–pyridine mixture. BBI derivatives containing two acylated amino groups were prepared with high yield. The use the reversible modifier citraconic anhydride first stage synthesis permitted hydrophobized retaining antitrypsin antichymotrypsin activities. It found that insertion long chain moieties molecule decreases its thermostability.
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