Herpes Simplex Virus Type 1 Interactions with the Interferon System.
作者： Kevin Danastas , Monica Miranda-Saksena , Anthony L. Cunningham
DOI: 10.3390/IJMS21145150
关键词: Human pathogen 、 Viral replication 、 Immune system 、 Interferon 、 Virology 、 Biology 、 Innate immune system 、 Gene 、 Secretion 、 Herpes simplex virus
摘要: The interferon (IFN) system is one of the first lines defense activated against invading viral pathogens. Upon secretion, IFNs activate a signaling cascade resulting in production several stimulated genes (ISGs), which work to limit replication and establish an overall anti-viral state. Herpes simplex virus type 1 ubiquitous human pathogen that has evolved downregulate IFN response lifelong latent infection sensory neurons host. This review will focus on mechanisms by host innate immune detects HSV-1 virions, subsequent generated infection, evasion strategies developed evade latency
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