DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells
作者： Boonrat Tassaneetrithep , Timothy H. Burgess , Angela Granelli-Piperno , Christine Trumpfheller , Jennifer Finke
DOI: 10.1084/JEM.20021840
关键词: Virology 、 Virus receptor 、 Antigen presentation 、 Antigen-presenting cell 、 Antibody-dependent enhancement 、 Dengue virus 、 Flavivirus 、 DC-SIGN 、 Biology 、 Dengue fever
摘要: Dengue virus is a single-stranded, enveloped RNA that productively infects human dendritic cells (DCs) primarily at the immature stage of their differentiation. We now find all four serotypes dengue use DC-SIGN (CD209), C-type lectin, to infect cells. THP-1 become susceptible infection after transfection DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN), or its homologue L-SIGN, whereas blocked by anti–DC-SIGN antibodies and not other molecules on these Viruses produced are infectious for DC-SIGN– L-SIGN–bearing permissive cell lines. Therefore, may be considered as new target designing therapies block infection.
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