Autoantibodies in rheumatoid arthritis: association with severity of disease in established RA

摘要: Introduction: Autoantibodies in rheumatoid arthritis (RA) are useful both for diagnosis and prognosis. Antibodies directed against citrullinated antigens have recently been shown to predict development of RA as well poor outcome early arthritis. Data on their role established is limited. We studied the association various autoantibodies with its severity. Materials methods: A total one hundred twenty nine-patients was enrolled sera were collected stored at −70°C. regarding erosions, deformities, extra-articular features collected. IgM factor (RF) measured using nephelometry value above 20 U considered positive. IgA RF by enzyme-linked immunosorbent assay (ELISA) mean±2 SD normal healthy control taken Anti-keratin antibody (AKA) detected indirect immunofluorescence rat esophagus substrate. Anti-cyclic peptide (CCP) antibodies commercial ELISA a 5 Results: The prevalence was: 82.2%, anti-CCP AKA 51.9%, anti 45%. concordance rate 83%, 68%, 60.5%. All but patient positive antibodies. presence RF, AKA, associated joint erosions deformities. None had any features. No seen or Among 23 seronegative patients, 11 6 deformities (p<0.05). Conclusion: Anti-CCP present majority patients including patients. Both addition conventional marker like severe erosive disease.