G Protein Pathways

摘要: The heterotrimeric guanine nucleotide-binding proteins (G proteins) are signal transducers that communicate signals from many hormones, neurotransmitters, chemokines, and autocrine paracrine factors. extracellular received by members of a large superfamily receptors with seven membrane-spanning regions activate the G proteins, which route to several distinct intracellular signaling pathways. These pathways interact one another form network regulates metabolic enzymes, ion channels, transporters, other components cellular machinery controlling broad range processes, including transcription, motility, contractility, secretion. processes in turn regulate systemic functions such as embryonic development, gonadal learning memory, organismal homeostasis.