New Dihydro-β-agarofuran Sesquiterpenes from Parnassia wightiana Wall: Isolation, Identification and Cytotoxicity against Cancer Cells
作者： Chao Lv , Zuo-Lue Zheng , Fang Miao , Hui-Ling Geng , Le Zhou
关键词: Cell culture 、 Celastraceae 、 Two-dimensional nuclear magnetic resonance spectroscopy 、 Cytotoxicity 、 Organic chemistry 、 In vitro 、 Stereochemistry 、 Sesquiterpene 、 Structure–activity relationship 、 Absolute configuration 、 Chemistry
摘要: Five new (4–8) and three known (1–3) dihydro-β-agarofuran sesquiterpene polyesters were isolated from the whole plants of Parnassia wightiana. The structures all compounds elucidated through spectroscopic analysis including 2D-NMR HR-MS. absolute configuration these was established by X-ray diffraction analysis, comparison NOESY spectra biogenetic means. cytotoxities 2–8 evaluated in vitro against HL-60, SMMC-7721, A549, MCF-7 SW480 cell lines. Compounds 5–7 exhibited highest activities with IC50 values 11.8–30.1 μM most cases. SAR revealed that introduction hydroxyl group able to significantly improve for
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