Treatment of recurrent epithelial ovarian cancer

作者: Sandro Pignata , Carmela Pisano , Giovanni Salvatore Bruni , Gaetano Facchini , Sandro Pignata

DOI: 10.2147/TCRM.S4317

关键词: Epithelial ovarian cancerOncologySurgeryTreatment regimenOverall survivalMedicineMortality rateChemotherapyDiseaseRecurrent diseaseOvarian cancerInternal medicine

摘要: Epidemiologic analysis reveals that the mortality rate from ovarian cancer is continuously decreasing due to improvement of surgery and chemotherapy. However, prognosis patients still unsatisfactory overall considering only 30% are alive after five years. In fact, although first-line systemic chemotherapy induces complete partial response in up 80% with about a 25% pathological remission rate, recurrences occur majority patients. The role recurrent disease has been recently studied many can receive an optimal secondary cytoreduction. Most subject number treatment regimens that, palliative nature, also able prolong survival. Important results have obtained particular platinum-sensitive where platinum-based progression-free survival Overall, our armamentarium for progressive or significantly richer than past, it possible achieve goal controlling chronic behavior disease.

参考文章(32)
Mohan K Tummala, William P McGuire, Recurrent ovarian cancer. Clinical advances in hematology & oncology. ,vol. 3, pp. 723- 736 ,(2005)
B Uziely, S Jeffers, R Isacson, K Kutsch, D Wei-Tsao, Z Yehoshua, E Libson, F M Muggia, A Gabizon, Liposomal doxorubicin: antitumor activity and unique toxicities during two complementary phase I studies. Journal of Clinical Oncology. ,vol. 13, pp. 1777- 1785 ,(1995) , 10.1200/JCO.1995.13.7.1777
W ten Bokkel Huinink, M Gore, J Carmichael, A Gordon, J Malfetano, I Hudson, C Broom, C Scarabelli, N Davidson, M Spanczynski, G Bolis, H Malmström, R Coleman, S C Fields, J F Heron, Topotecan versus paclitaxel for the treatment of recurrent epithelial ovarian cancer. Journal of Clinical Oncology. ,vol. 15, pp. 2183- 2193 ,(1997) , 10.1200/JCO.1997.15.6.2183
Alan N. Gordon, John T. Fleagle, David Guthrie, David E. Parkin, Martin E. Gore, Angel J. Lacave, Recurrent Epithelial Ovarian Carcinoma: A Randomized Phase III Study of Pegylated Liposomal Doxorubicin Versus Topotecan Journal of Clinical Oncology. ,vol. 19, pp. 3312- 3322 ,(2001) , 10.1200/JCO.2001.19.14.3312
Sandro Pignata, Gabriella Ferrandina, Giovanna Scarfone, Paolo Scollo, Franco Odicino, Luigi Selvaggi, Dionyssios Katsaros, Luigi Frigerio, Liliana Mereu, Fabio Ghezzi, Luigi Manzione, Rossella Lauria, Enrico Breda, Giovanna Marforio, Michela Ballardini, Alessandra Vernaglia Lombardi, Roberto Sorio, Salvatore Tumolo, Bruno Costa, Giovanna Magni, Francesco Perrone, Giuseppe Favalli, Extending the platinum-free interval with a non-platinum therapy in platinum-sensitive recurrent ovarian cancer. Results from the SOCRATES Retrospective Study Oncology. ,vol. 71, pp. 320- 326 ,(2006) , 10.1159/000108592
Neil S Horowitz, Jun Hua, Randall K Gibb, David G Mutch, Thomas J Herzog, The role of topotecan for extending the platinum-free interval in recurrent ovarian cancer: an in vitro model. Gynecologic Oncology. ,vol. 94, pp. 67- 73 ,(2004) , 10.1016/J.YGYNO.2004.03.047
Pierluigi Benedetti Panici, Antonio De Vivo, Filippo Bellati, Natalina Manci, Giorgia Perniola, Stefano Basile, Ludovico Muzii, Roberto Angioli, Secondary Cytoreductive Surgery in Patients with Platinum-Sensitive Recurrent Ovarian Cancer Annals of Surgical Oncology. ,vol. 14, pp. 1136- 1142 ,(2007) , 10.1245/S10434-006-9273-8