Antimicrobial peptides: Possible anti-infective agents.
作者： Jayaram Lakshmaiah Narayana , Jyh-Yih Chen
DOI: 10.1016/J.PEPTIDES.2015.05.012
关键词: Preliminary analysis 、 Immunology 、 Drug development 、 Antimicrobial peptides 、 Anti-Infective Agents 、 Antibiotics 、 Biology 、 Multiple drug resistance
摘要: Multidrug-resistant bacterial, fungal, viral, and parasitic infections are major health threats. The Infectious Diseases Society of America has expressed concern on the decrease pharmaceutical companies working antibiotic research development. However, small companies, along with academic institutes, stepping forward to develop novel therapeutic methods overcome present healthcare situation. Among leading alternatives current drugs antimicrobial peptides (AMPs), which abundantly distributed in nature. AMPs exhibit broad-spectrum activity against a wide variety bacteria, fungi, viruses, parasites, even cancerous cells. They also show potential immunomodulatory properties, highly responsive infectious agents innate immuno-stimulatory molecules. In recent years, many have undergone or undergoing clinical development, few commercially available for topical other applications. this review, we outline selected anion cationic at various stages from preliminary analysis drug Moreover, consider production delivery tools AMPs, must be improved effective use these agents.
elsevier.com
sci-hub.se 参考文章(125)
Victor Nizet, Antimicrobial peptide resistance mechanisms of human bacterial pathogens. Current Issues in Molecular Biology. ,vol. 8, pp. 11- 26 ,(2006)
Marie-Hélène Metz-Boutigue, Yannick Goumon, Karine Lugardon, Jean-Marc Strub, Dominique Aunis, Antibacterial Peptides Are Present in Chromaffin Cell Secretory Granules Cellular and Molecular Neurobiology. ,vol. 18, pp. 249- 266 ,(1998) , 10.1023/A:1022573004910
Jeremy P Bradshaw, Cationic antimicrobial peptides : issues for potential clinical use. BioDrugs. ,vol. 17, pp. 233- 240 ,(2003) , 10.2165/00063030-200317040-00002
Yuping Lai, Amer E. Villaruz, Min Li, David J. Cha, Daniel E. Sturdevant, Michael Otto, The human anionic antimicrobial peptide dermcidin induces proteolytic defence mechanisms in staphylococci Molecular Microbiology. ,vol. 63, pp. 497- 506 ,(2007) , 10.1111/J.1365-2958.2006.05540.X
A. Giacometti, O. Cirioni, G. Greganti, M. Quarta, G. Scalise, In vitro activities of membrane-active peptides against gram-positive and gram-negative aerobic bacteria. Antimicrobial Agents and Chemotherapy. ,vol. 42, pp. 3320- 3324 ,(1998) , 10.1128/AAC.42.12.3320
J. M. HARRINGTON, Antimicrobial peptide killing of African trypanosomes. Parasite Immunology. ,vol. 33, pp. 461- 469 ,(2011) , 10.1111/J.1365-3024.2011.01294.X
E Zahran, E J Noga, Evidence for synergism of the antimicrobial peptide piscidin 2 with antiparasitic and antioomycete drugs. Journal of Fish Diseases. ,vol. 33, pp. 995- 1003 ,(2010) , 10.1111/J.1365-2761.2010.01205.X
R Hipfel, B Schittek, Y Bodingbauer, C Garbe, Specifically regulated genes in malignant melanoma tissues identified by subtractive hybridization. British Journal of Cancer. ,vol. 82, pp. 1149- 1157 ,(2000) , 10.1054/BJOC.1999.1055
Kazunori Sagawa, Akihiko Kimura, Yoshifumi Saito, Hiroshi Inoue, Seiji Yasuda, Mizuho Nosaka, Tsutomu Tsuji, Production and characterization of a monoclonal antibody for sweat-specific protein and its application for sweat identification. International Journal of Legal Medicine. ,vol. 117, pp. 90- 95 ,(2003) , 10.1007/S00414-002-0341-8
G Mignogna, M Simmaco, D Barra, F Bossa, Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides. Journal of Biological Chemistry. ,vol. 269, pp. 11956- 11961 ,(1994) , 10.1016/S0021-9258(17)32666-2