Osteoblast cell response to hydroxyapatite of different heat treatments

作者: J.L. Ong , R. Cavin

DOI: 10.1109/SBEC.1997.583246

关键词: Osteoblast cellNuclear chemistryMineralogyPrecursor cellCrystalliteOsteoblastOsteocalcinCalcinationIn vitroCrystallizationChemistry

摘要: In vitro osteoblast precursor cell responses to characterized hydroxyapatite (HA) surfaces of different treatments were investigated. The sintered HA samples observed have the highest crystallite size compared as-received and calcined samples. As indicated by increased alkaline phosphatase specific activity 1,25 (OH/sub 2/) vitamin D/sub 3/ stimulated osteocalcin production, a more differentiated osteoblast-like phenotype was on surfaces.

参考文章(22)
Herman S. Cheung, Daniel J. McCarty, Mitogenesis induced by calcium-containing crystals Experimental Cell Research. ,vol. 157, pp. 63- 70 ,(1985) , 10.1016/0014-4827(85)90152-1
Paul A. Price, Vitamin K-Dependent Formation of Bone Gla Protein (Osteocalcin) and Its Function Vitamins and Hormones Series. ,vol. 42, pp. 65- 108 ,(1985) , 10.1016/S0083-6729(08)60061-8
R J Majeska, G A Rodan, The effect of 1,25(OH)2D3 on alkaline phosphatase in osteoblastic osteosarcoma cells. Journal of Biological Chemistry. ,vol. 257, pp. 3362- 3365 ,(1982) , 10.1016/S0021-9258(18)34781-1
R.Z. Legeros, Calcium Phosphate Materials in Restorative Dentistry: a Review Advances in Dental Research. ,vol. 2, pp. 164- 180 ,(1988) , 10.1177/08959374880020011101
B. Koch, J. G. C. Wolke, K. de Groot, X-ray diffraction studies on plasma-sprayed calcium phosphate-coated implants Journal of Biomedical Materials Research. ,vol. 24, pp. 655- 667 ,(1990) , 10.1002/JBM.820240603
D. D. Thompson, A. S. Posner, W. S. Laughlin, N. C. Blumenthal, Comparison of bone apatite in osteoporotic and normal Eskimos. Calcified Tissue International. ,vol. 35, pp. 392- 393 ,(1983) , 10.1007/BF02405064
L.C. Lucas, W.R. Lacefield, J.L. Ong, R.Y. Whitehead, Calcium phosphate coatings for medical and dental implants Colloids and Surfaces A: Physicochemical and Engineering Aspects. ,vol. 77, pp. 141- 147 ,(1993) , 10.1016/0927-7757(93)80110-Z
M. Jarcho, C. H. Bolen, M. B. Thomas, J. Bobick, J. F. Kay, R. H. Doremus, Hydroxylapatite synthesis and characterization in dense polycrystalline form Journal of Materials Science. ,vol. 11, pp. 2027- 2035 ,(1976) , 10.1007/PL00020328