Investigation of prepubertal sex differences in wheel running and social behavior in three mouse strains

摘要: Sex differences in social behaviors exist mammals during adulthood, and further evidence suggests that sex behavior are present before sexual maturity. In order to model behavioral disorders animals, it is important assess baseline sex-related differences, especially when studying for which effects expected. We investigated the effect of on 3 strains pre-pubertal mice (C57BL/6, CFW, CF1) using a wheel-running assay. found no significant latency run wheel or total duration running within each strain. During interaction test, there were between sexes contact following subject novel mouse. also evaluated patterns stereotypical behaviors, such as burrowing grooming. Both showed characteristic behavior, spending majority trial interacting with was free more time performing other activities (e.g., general locomotion) jammed. These results provide that, among various mice, not strong enough influence measured behaviors.