Treatment of epithelial ovarian cancer.

作者: Lindsay Kuroki , Saketh R Guntupalli

DOI: 10.1136/BMJ.M3773

关键词: Internal medicineCarcinomaGenetic testingImmunotherapyMedicineMaintenance therapyCombined Modality TherapyOvarian cancerOncologyBevacizumabGene mutation

摘要: Ovarian cancer is the third most common gynecologic malignancy worldwide but accounts for highest mortality rate among these cancers. A stepwise approach to assessment, diagnosis, and treatment vital appropriate management of this disease process. An integrated with oncologists as well medical oncologists, pathologists, radiologists paramount importance improving outcomes. Surgical cytoreduction R0 mainstay treatment, followed by adjuvant chemotherapy. Genetic testing gene mutations that affect standard care all women epithelial ovarian cancer. Nearly will have a recurrence, recurrent continues be nuanced requires extensive review up date modalities balance efficacy patient's quality life. Maintenance therapy poly ADP-ribose polymerase inhibitors, bevacizumab, and/or drugs targeting homologous recombination deficiency becoming more widely used in cancer, advancement immunotherapy further revolutionizing targets.

参考文章(130)
Alan N. Gordon, John T. Fleagle, David Guthrie, David E. Parkin, Martin E. Gore, Angel J. Lacave, Recurrent Epithelial Ovarian Carcinoma: A Randomized Phase III Study of Pegylated Liposomal Doxorubicin Versus Topotecan Journal of Clinical Oncology. ,vol. 19, pp. 3312- 3322 ,(2001) , 10.1200/JCO.2001.19.14.3312
Angiolo Gadducci, Stefania Cosio, Surveillance of patients after initial treatment of ovarian cancer. Critical Reviews in Oncology Hematology. ,vol. 71, pp. 43- 52 ,(2009) , 10.1016/J.CRITREVONC.2008.12.008
J. Alejandro Rauh-Hain, Caroline C. Nitschmann, Micheal J. Worley, Leslie S. Bradford, Ross S. Berkowitz, John O. Schorge, Susana M. Campos, Marcela G. del Carmen, Neil S. Horowitz, Platinum resistance after neoadjuvant chemotherapy compared to primary surgery in patients with advanced epithelial ovarian carcinoma Gynecologic Oncology. ,vol. 129, pp. 63- 68 ,(2013) , 10.1016/J.YGYNO.2013.01.009
Rowan E Miller, Gordon JS Rustin, How to follow-up patients with epithelial ovarian cancer. Current Opinion in Oncology. ,vol. 22, pp. 498- 502 ,(2010) , 10.1097/CCO.0B013E32833AE8B6
U Wagner, C Marth, R Largillier, J Kaern, C Brown, M Heywood, T Bonaventura, I Vergote, M C Piccirillo, R Fossati, V Gebski, E P Lauraine, Final overall survival results of phase III GCIG CALYPSO trial of pegylated liposomal doxorubicin and carboplatin vs paclitaxel and carboplatin in platinum-sensitive ovarian cancer patients British Journal of Cancer. ,vol. 107, pp. 588- 591 ,(2012) , 10.1038/BJC.2012.307
Jean-Luc Brun, Roman Rouzier, Serge Uzan, Emile Daraï, External validation of a laparoscopic-based score to evaluate resectability of advanced ovarian cancers: Clues for a simplified score Gynecologic Oncology. ,vol. 110, pp. 354- 359 ,(2009) , 10.1016/J.YGYNO.2008.04.042
Robert S. Mannel, Mark F. Brady, Elise C. Kohn, Parviz Hanjani, Masamichi Hiura, Roger Lee, Koen DeGeest, David E. Cohn, Bradley J. Monk, Helen Michael, A randomized phase III trial of IV carboplatin and paclitaxel × 3 courses followed by observation versus weekly maintenance low-dose paclitaxel in patients with early-stage ovarian carcinoma: A Gynecologic Oncology Group Study Gynecologic Oncology. ,vol. 122, pp. 89- 94 ,(2011) , 10.1016/J.YGYNO.2011.03.013