作者: Lindsay Kuroki , Saketh R Guntupalli
DOI: 10.1136/BMJ.M3773
关键词: Internal medicine 、 Carcinoma 、 Genetic testing 、 Immunotherapy 、 Medicine 、 Maintenance therapy 、 Combined Modality Therapy 、 Ovarian cancer 、 Oncology 、 Bevacizumab 、 Gene mutation
摘要: Ovarian cancer is the third most common gynecologic malignancy worldwide but accounts for highest mortality rate among these cancers. A stepwise approach to assessment, diagnosis, and treatment vital appropriate management of this disease process. An integrated with oncologists as well medical oncologists, pathologists, radiologists paramount importance improving outcomes. Surgical cytoreduction R0 mainstay treatment, followed by adjuvant chemotherapy. Genetic testing gene mutations that affect standard care all women epithelial ovarian cancer. Nearly will have a recurrence, recurrent continues be nuanced requires extensive review up date modalities balance efficacy patient's quality life. Maintenance therapy poly ADP-ribose polymerase inhibitors, bevacizumab, and/or drugs targeting homologous recombination deficiency becoming more widely used in cancer, advancement immunotherapy further revolutionizing targets.