Association of human leukocyte antigen DQB1 and DRB1 alleles with chronic hepatitis B

摘要: AIM: To investigate the effect of human leukocyte antigen (HLA) DRB1 and DQB1 alleles on inactive advanced stages chronic hepatitis B. METHODS: Patient records at a single institution’s hepatology clinic were reviewed. Demographic data, laboratory results, endoscopy virological parameters, biopsy scores treatment statuses recorded. In total, 355 patients eligible for study, whom 226 (63.7%) male. Overall, 82 (23.1%) B early (HBeAg) positive, 87 (24.5%) had cirrhosis, 66 (18.6%) disease. The presence was determined by polymerase chain reaction with sequence-specific primers. distribution genotyped among cirrhosis active analyzed. RESULTS: most frequent HLA allele DQB1*03:01 (48.2%), DRB1*13/14 (51.8%). DQB1*05:01 more in disease than (27% vs 9.1%; P = 0.002, Pc 0.026). DRB1*07 rare compared non-cirrhotics (3.4% 16%; 0.022). Older age (P < 0.001) male gender 0.008) other factors that affected cirrhosis. multivariate logistic regression analysis, remained significant negative predictor 0.015). A bioinformatics analysis revealed polymorphic amino acid sequence may alter interaction T-cell recognition site. CONCLUSION: This study demonstrates influence development activity Turkish patients.