Cocaine and metabolites in waste and surface water across Belgium.
作者： Alexander L.N. van Nuijs , Bert Pecceu , Laetitia Theunis , Nathalie Dubois , Corinne Charlier
DOI: 10.1016/J.ENVPOL.2008.07.020
关键词: River water 、 Ecgonine methyl ester 、 Liquid chromatography–mass spectrometry 、 Benzoylecgonine 、 Population 、 Surface water 、 Cocaine abuse 、 Chemistry 、 Environmental chemistry
摘要: Cocaine abuse, a growing social problem, is currently estimated from population surveys, consumer interviews and crime statistics. A new approach based on the analysis of cocaine (COC) metabolites, benzoylecgonine (BE) ecgonine methyl ester (EME), in water samples was applied to 28 rivers 37 waste treatment plants Belgium using solid-phase extraction liquid chromatography coupled tandem mass spectrometry. While EME undetectable, COC BE were detectable with concentrations ranging <1 753 ng/L 2258 ng/L, respectively. employed calculate local amount abused cocaine. The highest values (up 1.8 g/day per 1000 inhabitants) found large cities during weekends. estimation abuse through can be executed regular basis without cooperation patients. It also gives clear geographical information, while prevention campaigns easily implemented evaluated.
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sci-hub.se 参考文章(19)
Joan M. Lakoski, Matthew P. Galloway, Francis J. White, Cocaine : pharmacology, physiology, and clinical strategies CRC Press. ,(1992)
Ettore Zuccato, Chiara Chiabrando, Sara Castiglioni, Davide Calamari, Renzo Bagnati, Silvia Schiarea, Roberto Fanelli, Cocaine in surface waters: a new evidence-based tool to monitor community drug abuse Environmental Health. ,vol. 4, pp. 14- 14 ,(2005) , 10.1186/1476-069X-4-14
H. E. Hamilton, J. E. Wallace, E. L. Shimek, P. Land, S. C. Harris, J. G. Christenson, Cocaine and benzoylecgonine excretion in humans. Journal of Forensic Sciences. ,vol. 22, pp. 697- 707 ,(1977) , 10.1520/JFS10408J
Ettore Zuccato, Sara Castiglioni, Renzo Bagnati, Chiara Chiabrando, Paola Grassi, Roberto Fanelli, Illicit drugs, a novel group of environmental contaminants. Water Research. ,vol. 42, pp. 961- 968 ,(2008) , 10.1016/J.WATRES.2007.09.010
Maria Huerta-Fontela, Maria Teresa Galceran, Francesc Ventura, Ultraperformance Liquid Chromatography−Tandem Mass Spectrometry Analysis of Stimulatory Drugs of Abuse in Wastewater and Surface Waters Analytical Chemistry. ,vol. 79, pp. 3821- 3829 ,(2007) , 10.1021/AC062370X
Edward J. Cone, Abraham Tsadik, Jonathan Oyler, William D. Darwin, Cocaine metabolism and urinary excretion after different routes of administration. Therapeutic Drug Monitoring. ,vol. 20, pp. 556- 560 ,(1998) , 10.1097/00007691-199810000-00019
Adriana Gheorghe, Alexander van Nuijs, Bert Pecceu, Lieven Bervoets, Philippe G. Jorens, Ronny Blust, Hugo Neels, Adrian Covaci, Analysis of cocaine and its principal metabolites in waste and surface water using solid-phase extraction and liquid chromatography–ion trap tandem mass spectrometry Analytical and Bioanalytical Chemistry. ,vol. 391, pp. 1309- 1319 ,(2008) , 10.1007/S00216-007-1754-5
Barbara Kasprzyk-Hordern, Richard M. Dinsdale, Alan J. Guwy, Multiresidue methods for the analysis of pharmaceuticals, personal care products and illicit drugs in surface water and wastewater by solid-phase extraction and ultra performance liquid chromatography-electrospray tandem mass spectrometry. Analytical and Bioanalytical Chemistry. ,vol. 391, pp. 1293- 1308 ,(2008) , 10.1007/S00216-008-1854-X
Barbara Kasprzyk-Hordern, Richard M. Dinsdale, Alan J. Guwy, The occurrence of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs in surface water in South Wales, UK. Water Research. ,vol. 42, pp. 3498- 3518 ,(2008) , 10.1016/J.WATRES.2008.04.026
Sara Castiglioni, Ettore Zuccato, Elisabetta Crisci, Chiara Chiabrando, Roberto Fanelli, Renzo Bagnati, Identification and Measurement of Illicit Drugs and Their Metabolites in Urban Wastewater by Liquid Chromatography−Tandem Mass Spectrometry Analytical Chemistry. ,vol. 78, pp. 8421- 8429 ,(2006) , 10.1021/AC061095B