Catechol-O-methyltransferase inhibition alters pain and anxiety-related volitional behaviors through activation of β-adrenergic receptors in the rat.

摘要: Abstract Reduced catechol-O-methyltransferase (COMT) activity resulting from genetic variation or pharmacological depletion results in enhanced pain perception humans and nociceptive behaviors animals. Using phasic mechanical thermal reflex tests (e.g. von Frey, Hargreaves), recent studies show that acute COMT-dependent rats is mediated by β-adrenergic receptors (βARs). In order to more closely mimic the characteristics of human chronic conditions associated with prolonged reductions COMT, present study sought determine volitional pain-related anxiety-like behavioral responses following sustained as well COMT inhibition using an operant 10–45 °C place preference task a light/dark test. addition, we evaluate effects on generalized body measuring tactile sensory thresholds abdominal region. Results demonstrated administration inhibitor OR486 increased behavior response heat. Further, anxiety bright light, mechanosensation. Finally, all were blocked non-selective βAR antagonist propranolol. Collectively, these findings provide first evidence stimulation βARs drives cognitive-affective heightened affects multiple sites.