Eutypellenoids A–C, New Pimarane Diterpenes from the Arctic Fungus Eutypella sp. D-1
作者： Hao-Bing Yu , Xiao-Li Wang , Wei-Heng Xu , Yi-Xin Zhang , Yi-Sen Qian
DOI: 10.3390/MD16080284
关键词: Diterpene 、 Circular dichroism 、 Candida tropicalis 、 Antibacterial activity 、 Escherichia coli 、 Candida albicans 、 Stereochemistry 、 Staphylococcus aureus 、 Chemistry 、 Candida glabrata
摘要: Three new pimarane diterpenes, eutypellenoids A⁻C (1⁻3), together with a known compound, eutypenoid C (4), were isolated from the culture extract of Eutypella sp. D-1 derived Arctic region. Compounds 1⁻3 possessed an uncommon tetrahydrofuran-fused diterpene skeleton. The structures all compounds determined by detailed spectroscopic analysis, electronic circular dichroism (ECD) as well comparison literature data. Antibacterial, antifungal, and cytotoxic activities these evaluated. Compound 2 displayed antibacterial activity against Staphylococcus aureus Escherichia coli MIC values 8 μg/mL, respectively. Additionally, compound showed antifungal Candidaparapsilosis, Candida albicans, glabrata, tropicalis 8, 16, 32 Furthermore, exhibited moderate HCT-116 cell line IC50 value 3.7 μM.
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