Morphogenesis in Paracoccidioides brasiliensis

摘要: Paracoccidioidomycosis (PCM) is a deep systemic mycosis originally described in 1908 caused by the ascomycete Paracoccidioides brasiliensis, thermodimorphic fungal pathogen. The disease autochthonous to Latin America and areas of higher incidence occur countries such as Brazil, Argentina, Colombia, Venezuela. Inside mammalian host, PCM characterized granulomatous inflammation that invades conjunctival tissue or viscera. P. brasiliensis grows yeast cultures incubated at 37°C inside host filamentous saprophytic form low temperatures (26°C) environmental niches. relative temperature-dependent simplistic mechanisms whereby orchestrates its developmental program for switching morphological forms have been under intense scrutiny several decades, although major advances achieved, much remains be uncovered identification new virulence determinants therapeutical targets, comprehension pathophysiology this fungus. Although recent studies begun identify genes overall pathways required process pathogenicity, master regulators mediating morphogenesis, virulence, mycelium-to-yeast transition are still not recognized. Transcriptional profiling highlighted importance differential expression mycelial phases analyzed putative involved morphogenesis based on evidences from other dimorphic fungi traits. Here, we consider current information obtained transcriptional level basis an update main pathogenicity fungus, experimental possibilities generated newly released genomic sequences will drive forthcoming years systematic research brasiliensis.