Cell biology of mitochondrial dynamics.

摘要: Mitochondria are the product of an ancient endosymbiotic event between α‐proteobacterium and archael host. An early barrier to overcome in this relationship was control bacterium's proliferation within Undoubtedly, bacterium (or protomitochondrion) would have used its own cell division apparatus divide at first and, today a remnant system remains some “ancient” diverse eukaryotes such as algae amoebae, most conserved widespread all bacterial proteins, FtsZ. In many that still use FtsZ constrict mitochondria from inside, resemble bacteria shape size. Eukaryotes, however, mitochondrial morphology is often highly fluid, their tubular networks mitochondria, clearly complemented by fusion. no longer these complex eukaryotes, may been replaced other proteins better suited sustaining networks. Although inside just beginning be characterized higher known act on outside organelle. The dynamin‐like which appear recruited very evolution mitochondria. essential nature dictates loss intolerable human cells, mutations disrupting more likely fatal than result disease. To date, only one disease (Charcot‐Marie‐Tooth 2A) has mapped gene required for division, whereas two diseases can attributed fusion genes. Apart playing role regulating morphology, might important efficient ATP production, research indicated also during apoptosis; fragmentation triggering (and under stimuli, essential) step pathway suicide.